PARTICLE-MEDIATED INTRAVENOUS DELIVERY OF ANTIGEN MRNA RESULTS IN STRONG ANTIGEN-SPECIFIC T-CELL RESPONSES DESPITE THE INDUCTION OF TYPE I INTERFERON

Cancer vaccines based on mRNA are extensively studied.The fragile nature of mRNA has instigated research into carriers that can protect it from ribonucleases and as such enable its systemic use.However, copyright-mediated delivery of mRNA has been linked to production of type I interferon (IFN) that was reported to compromise the effectiveness of m

Abstract The use of micropropagation techniques is crucial for the conservation of endangered moss species and their reestablishment in nature.This study aimed to establish in vitro cultures of gametophyte fragments of ten species of Cerrado mosses.After disinfestation with Food Storage Containers alcohol and commercial bleach, moss explants were g

Languages continue to develop, modify, and reshape during unprecedented situations (Paton, 2020).Language fluidity and its flexible nature tend to be weapons in the hands of linguists and artists to cope with unprecedented difficult times.The current situation caused by the COVID-19 pandemic is posing significant socio-cultural challenges globally

Introduction The consumption of dairy products contributes to health, nutrition, and livelihoods globally.However, dairy products do not come without microbiological food safety risks for consumers.Despite this risk, common hygiene measures in high-income countries, particularly pasteurisation, ensures that milk is safe, and is indeed frequently ma

Automatic feature extraction from images of speech articulators is currently achieved by detecting edges.Here, we investigate the use of pose estimation deep neural nets with transfer learning to perform markerless estimation of speech articulator keypoints using Meters only a few hundred hand-labelled images as training input.Midsagittal ultrasoun